Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


___


Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


___


Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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Consumer sentiment at year low; fiscal debate weighs

NEW YORK (Reuters) - Consumer sentiment unexpectedly deteriorated for a second straight month to its lowest in over a year in January, with many consumers citing fallout from the recent "fiscal cliff" debate in Washington, a survey released on Friday showed.


The sharp drop in sentiment over the last two months coincides with rancorous federal budget negotiations that have led to higher taxes for many Americans.


Just weeks after that deal, President Barack Obama and Republican lawmakers are expected to enter another tough round of negotiations over spending cuts, which could dent consumer confidence still further.


"The handling of the fiscal cliff talks and the realization that paychecks are going to be smaller due to the sunset of the payroll tax holiday are probably weighing on consumer attitudes at the moment," said Thomas Simons, a money market economist at Jefferies & Co. in New York.


While most of the scheduled tax hikes and spending cuts forming the fiscal cliff were avoided when Congress struck a deal on January 1, most U.S. workers saw their take-home salary diminished by the expiry of two percentage-point cut in payroll taxes.


"With the debt ceiling yet to be tackled and more political acrimony on the way, we suspect that confidence has room to deteriorate further," Simons said.


The Thomson Reuters/University of Michigan's preliminary reading on the overall index of consumer sentiment came in at 71.3, down from 72.9 the month before. The index was at its lowest since December 2011. It was also below the median forecast of 75 among economists polled by Reuters.


"The most unique aspect of the early January data was that an all-time record number of consumers - 35 percent - negatively referred to the fiscal cliff negotiations," survey director Richard Curtin said in a statement.


"Importantly, the debt ceiling debate is still upcoming and could further weaken confidence," he said.


House Republicans have signaled they might support a short-term extension of U.S. borrowing authority when the government exhausts that capacity sometime between mid-February and early March. A failure by Congress to raise this debt ceiling could result in a market-rattling government default.


On Friday, Republican House Majority Leader Eric Cantor said the House would consider a bill next week to extend the debt limit by three months in order to force the Senate to pass a budget.


U.S. stocks remained little changed after the data. The S&P 500 <.spx> hit a five-year high in the last session. But on Friday, a weak outlook from Intel offset encouraging data out of China and a fourth-quarter profit at Morgan Stanley .


So far there has been a disconnect between what consumers say and do. U.S. retail sales increased a better-than-expected 0.5 percent in December. But given the recent weakening in sentiment investors will be watching for any signs that spending is starting to slip.


"The impact on consumers will be from the hike in the social security tax. That is undoubtedly going to hit discretionary spending. So this may be a signal of things to come," said Michael Woolfolk, a senior currency strategist at BNY Mellon in New York.


The consumer survey's barometer of current economic conditions fell to 84.8 from 87.0 and was below a forecast of 88.0. The gauge hit its lowest since July.


The survey's gauge of consumer expectations also slipped, hitting its lowest since November 2011 at 62.7 from 63.8, and was below an expected 65.2.


The survey's one-year inflation expectations rose to 3.4 percent from 3.2 percent, while the survey's five-to-10-year inflation outlook was unchanged at 2.9 percent.


(Additional reporting by Steven C. Johnson and Ellen Freilich; Editing by Andrea Ricci)



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The Lede Blog: Live Updates on Armstrong's Confession

As the second part of Lance Armstrong’s televised confession that he doped and lied his way to seven Tour de France titles is broadcast on the Oprah Winfrey Network Friday night, The Lede will have real-time fact-checking and analysis from New York Times reporters, including Juliet Macur and Naila-Jean Meyers. We will also round up reactions from fans, bloggers, journalists and fellow riders once the broadcast and live stream gets underway, at 9 p.m. Eastern Time.
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Video game puts players in shoes of Syrian rebels






BEIRUT (AP) — A new video game based on Syria‘s civil war challenges players to make the hard choices facing the country’s rebels. Is it better to negotiate peace with the regime of President Bashar Assad, for example, or dispatch jihadist fighters to kill pro-government thugs?


The British designer of “Endgame: Syria” says he hopes the game will inform people who might otherwise remain ignorant about the conflict.






Views differ, however, on the appropriateness of using a video game to discuss a complex crisis that has killed more than 60,000 people since March 2011. Computer giant Apple has refused to distribute the game and some consider the mere idea insulting. Others love it, and one fan from inside Syria has suggested changes to make the game better mirror the actual war.


The dispute comes amid wider arguments about violent video games since last month’s shooting in Newtown, Connecticut, that left 20 children and six adults dead. This week, the National Rifle Association revised the recommended age for a new shooting game after criticisms by liberal groups.


Tomas Rawlings, who designed the Syria game, said he got the idea while watching TV pundits debate the possible consequences of directly arming Syria’s rebels, which Western nations have declined to do. He said he thought a game could explore such questions by allowing players to make choices and see their consequences.


“For those who don’t want to read a newspaper but still care about the world, this is a way for them to find out about things,” said Rawlings, the design and production director of U.K.-based Auroch Digital.


In the simple game, which took about two weeks to build, the player assumes the role of the rebels seeking to topple Assad’s regime. The play alternates between political and military stages. In each stage, the player sees cards representing regime actions and must choose the rebel response.


The choices seek to mirror the real conflict. The regime may get declarations of support from Russia, China or Iran to boost its popularity while the rebels receive support from the United States, Turkey or Saudi Arabia – reflecting the foreign powers backing the two sides.


In battle, the regime may deploy conventional military forces like infantry, tanks and artillery as well as pro-government thugs known as shabiha. The rebels’ choices include sympathetic Palestinian or Kurdish militias, assassins or jihadist fighters known as muhajideen.


Some of the rebels’ strongest attacks also kill civilians, reducing rebel popularity and seeking to reflect the war’s complexity.


All along, the player is given basic information about the conflict, learning that Islamists once persecuted by the regime now consider the fight a holy war and that the shabiha are accused of massacring civilians.


The game ends when one side loses its support or the sides agree to a peace deal. The player is then told what follows. The longer the fighting lasts, the worse the aftermath, as chaos, sectarian conflict and Islamic militancy spread.


The lasting impression is that no matter which side wins, Syria loses.


Rawlings said that’s the game’s point.


“You can win the battle militarily but still lose the peace because the cost of winning militarily has fractured the country so much that the war keeps going,” he said. “You can also end the war so that there is less of that.”


The game was released on the company’s website and as a free download from Google for Android devices on December 12. Rawlings submitted the game to Apple to distribute via its App Store but the company rejected it.


Apple declined to comment, but Rawlings’s rejection referred to a company guideline for mobile apps: ” ‘Enemies’ within the context of a game cannot solely target a specific race, culture, a real government or corporation, or any other real entity.”


Rawlings is modifying the game, though he worries it will weaken it.


“It will still be the same overall experience, but it will reduce the value of the game to inform people,” he said.


News of the game was greeted with a mix of interest and outrage online. Some complained that players can’t take the regime side, while others found it wrong to make a game about a brutal war.


“Rawlings has mistakenly understood the Syrian war as a nonchalant ‘experience’ that people can play while waiting for the train to work,” said Samar Aburahma, a university student of Palestinian descent in San Francisco who refused to try the game. “It is beyond insulting to Syrians, especially given the fact that war is ongoing.”


Others find it a valuable, if limited, approach to the conflict.


Andrea Stanton, a religious studies professor at the University of Denver who studies Syria, said she responded emotionally to the game.


“It isn’t really a fun game to play,” she said, noting that she was angry when she lost and felt dread when the frequency of deadly regime airstrikes went up as the game progressed – as it has in the real conflict.


“This a very sobering game in that you sense how quickly the military stakes escalate and how little the political phase has to do with actual Syrians,” she said.


She is organizing a campus activity for students to play and discuss the game.


“I think it is very valuable for teaching and getting people to experience a sense of the limited options the rebels face,” she said.


It is unclear how many people have played the game. Google says it has been downloaded as many as 5,000 times from its site, and Rawlings says more have played online. He guesses more than 10,000 people have tried it.


Few in Syria are likely to have played it, since fighting has made the Internet and even electricity rare in some parts of the country.


One 18-year-old Syrian gamer liked the game so much, however, that he sent Rawlings a list of suggestions for improvement.


Reached via Skype, he said the jihadist fighters should be called Jabhat al-Nusra, after an extremist rebel group that the U.S. has designated as a terrorist organization.


He also pointed out that few rebel groups have tanks, as they do in the game, and suggested new rebel tactics.


“Car bombs are used lots in Syria, so that would make the game more realistic,” he said.


He said he hoped the game would help people understand the situation.


“I wish there were a 3D strategy game about Syria so you could feel the destruction on the ground,” he said.


The player, who spoke on condition of anonymity for fear of reprisals, said his feelings playing the game often mirror his feelings about the war. He wants peace but can’t imagine the rebels accepting a negotiated solution given how many people have died.


“Right this second, I want the war in Syria to stop, but when you see what is happening on the ground there is no way to make peace,” he said. “When I play the game like a rebel, I have to reject the peace.”


___


Associated Press writer Michael Liedtke contributed reporting.


Online: http://gamethenews.net/index.php/endgame-syria/


Gaming News Headlines – Yahoo! News





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See Personal Pics of Rosie O'Donnell's Daughter Dakota




After welcoming her fifth child, the comedian gives fans an intimate glimpse into her mommy joy in a series of personal photos








Credit: Courtesy of Rosie O'Donnell



Updated: Thursday Jan 17, 2013 | 12:00 PM EST
By: Shanelle Rein-Olowokere




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Will Obama's order lead to surge in gun research?


MILWAUKEE (AP) — Nearly as many Americans die from guns as from car crashes each year. We know plenty about the second problem and far less about the first. A scarcity of research on how to prevent gun violence has left policymakers shooting in the dark as they craft gun control measures without much evidence of what works.


That could change with President Barack Obama's order Wednesday to ease research restrictions pushed through long ago by the gun lobby. The White House declared that a 1996 law banning use of money to "advocate or promote gun control" should not keep the Centers for Disease Control and Prevention and other federal agencies from doing any work on the topic.


Obama can only do so much, though. Several experts say Congress will have to be on board before anything much changes, especially when it comes to spending money.


How severely have the restrictions affected the CDC?


Its website's A-to-Z list of health topics, which includes such obscure ones as Rift Valley fever, does not include guns or firearms. Searching the site for "guns" brings up dozens of reports on nail gun and BB gun injuries.


The restrictions have done damage "without a doubt" and the CDC has been "overly cautious" about interpreting them, said Daniel Webster, director of the Center for Gun Policy and Research at the Johns Hopkins Bloomberg School of Public Health.


"The law is so vague it puts a virtual freeze on gun violence research," said a statement from Michael Halpern of the Union of Concerned Scientists. "It's like censorship: When people don't know what's prohibited, they assume everything is prohibited."


Many have called for a public health approach to gun violence like the highway safety measures, product changes and driving laws that slashed deaths from car crashes decades ago even as the number of vehicles on the road rose.


"The answer wasn't taking away cars," said Dr. Georges Benjamin, executive director of the American Public Health Association.


However, while much is known about vehicles and victims in crashes, similar details are lacking about gun violence.


Some unknowns:


—How many people own firearms in various cities and what types.


—What states have the highest proportion of gun ownership.


—Whether gun ownership correlates with homicide rates in a city.


—How many guns used in homicides were bought legally.


—Where juveniles involved in gun fatalities got their weapons.


—What factors contribute to mass shootings like the Newtown, Conn., one that killed 26 people at a school.


"If an airplane crashed today with 20 children and 6 adults there would be a full-scale investigation of the causes and it would be linked to previous research," said Dr. Stephen Hargarten, director of the Injury Research Center at the Medical College of Wisconsin.


"There's no such system that's comparable to that" for gun violence, he said.


One reason is changes pushed by the National Rifle Association and its allies in 1996, a few years after a major study showed that people who lived in homes with firearms were more likely to be homicide or suicide victims. A rule tacked onto appropriations for the Department of Health and Human Services barred use of funds for "the advocacy or promotion of gun control."


Also, at the gun group's urging, U.S. Rep. Jay Dickey, a Republican from Arkansas, led an effort to remove $2.6 million from the CDC's injury prevention center, which had led most of the research on guns. The money was later restored but earmarked for brain injury research.


"What the NRA did was basically terrorize the research community and terrorize the CDC," said Dr. Mark Rosenberg, who headed the CDC's injury center at the time. "They went after the researchers, they went after institutions, they went after CDC in a very big way, and they went after me," he said. "They didn't want the data to be collected because they were threatened by what the data were showing."


Dickey, who is now retired, said Wednesday that his real concern was the researcher who led that gun ownership study, who Dickey described as being "in his own kingdom or fiefdom" and believing guns are bad.


He and Rosenberg said they have modified their views over time and now both agree that research is needed. They put out a joint statement Wednesday urging research that prevents firearm injuries while also protecting the rights "of legitimate gun owners."


"We ought to research the whole environment, both sides — what the benefits of having guns are and what are the benefits of not having guns," Dickey said. "We should study any part of this problem," including whether armed guards at schools would help, as the National Rifle Association has suggested.


Association officials did not respond to requests for comment. A statement Wednesday said the group "has led efforts to promote safety and responsible gun ownership" and that "attacking firearms" is not the answer. It said nothing about research.


The 1996 law "had a chilling effect. It basically brought the field of firearm-related research to a screeching halt," said Benjamin of the Public Health Association.


Webster said researchers like him had to "partition" themselves so whatever small money they received from the CDC was not used for anything that could be construed as gun policy. One example was a grant he received to evaluate a community-based program to reduce street gun violence in Baltimore, modeled after a successful program in Chicago called CeaseFire. He had to make sure the work included nothing that could be interpreted as gun control research, even though other privately funded research might.


Private funds from foundations have come nowhere near to filling the gap from lack of federal funding, Hargarten said. He and more than 100 other doctors and scientists recently sent Vice President Joe Biden a letter urging more research, saying the lack of it was compounding "the tragedy of gun violence."


Since 1973, the government has awarded 89 grants to study rabies, of which there were 65 cases; 212 grants for cholera, with 400 cases, yet only three grants for firearm injuries that topped 3 million, they wrote. The CDC spends just about $100,000 a year out of its multibillion-dollar budget on firearm-related research, New York Mayor Michael Bloomberg has said.


"It's so out of proportion to the burden, however you measure it," said Dr. Matthew Miller, associate professor of health policy at the Harvard School of Public Health. As a result, "we don't know really simple things," such as whether tighter gun rules in New York will curb gun trafficking "or is some other pipeline going to open up" in another state, he said.


What now?


CDC officials refused to discuss the topic on the record — a possible sign of how gun shy of the issue the agency has been even after the president's order.


Health and Human Services Secretary Kathleen Sebelius said in a statement that her agency is "committed to re-engaging gun violence research."


Others are more cautious. The Union of Concerned Scientists said the White House's view that the law does not ban gun research is helpful, but not enough to clarify the situation for scientists, and that congressional action is needed.


Dickey, the former congressman, agreed.


"Congress is supposed to do that. He's not supposed to do that," Dickey said of Obama's order. "The restrictions were placed there by Congress.


"What I was hoping for ... is 'let's do this together,'" Dickey said.


___


Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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Housing, job data push S&P to five-year high; Intel down late

NEW YORK (Reuters) - Stronger-than-expected data on housing starts and jobless claims lit a fire under stocks on Thursday, pushing the S&P 500 to a five-year high and its third day of gains.


A pair of economic reports lifted investors' sentiment. The number of Americans filing new claims for unemployment benefits fell to a five-year low last week and housing starts jumped last month to the highest since June 2008.


Strength in the housing and labor markets is key to sustained growth and higher corporate profits, helping to bring out buyers even on a day when earnings reports were mixed.


Gains were tempered by weakness in the financial sector, with Bank of America down 4.2 percent to $11.28 and Citigroup off 2.9 percent to $41.24 after their results.


In other negative earnings news, shares of chipmaker Intel fell 5.2 percent to $21.49 in extended-hours trading after the company forecast quarterly revenue that fell short of analysts' expectations. Intel had ended the regular session up 2.6 percent at $22.68.


The S&P 500 ended at its highest since December 2007 and now sits just 5.6 percent from its all-time closing high of 1,565.15.


"Having consolidated really for the last two weeks, the fact that we broke out, I think that that is sucking in quite a bit of money," said James Dailey, portfolio manager of TEAM Asset Strategy Fund in Harrisburg, Pennsylvania.


The Dow Jones industrial average <.dji> was up 84.79 points, or 0.63 percent, at 13,596.02. The Standard & Poor's 500 Index <.spx> was up 8.31 points, or 0.56 percent, at 1,480.94. The Nasdaq Composite Index <.ixic> was up 18.46 points, or 0.59 percent, at 3,136.00.


Better-than-expected earnings and revenue reported by online marketplace eBay late Wednesday helped the stock gain 2.7 percent to $54.33.


In the housing sector, PulteGroup Inc shares gained 4.9 percent to $20.29 and Toll Brothers Inc advanced 3.1 percent to $35.99. The PHLX housing sector index <.hgx> climbed 2.4 percent, reaching its highest close since August 2007.


Semiconductor shares <.sox> rose 2 percent to the highest close in eight months.


Financials were the only S&P 500 sector to register a slight decline for the day.


Bank of America's fourth-quarter profit fell as it took more charges to clean up mortgage-related problems. Citigroup posted $2.32 billion of charges for layoffs and lawsuits.


Energy shares led gains on the Dow as U.S. crude oil prices jumped more than 1 percent. Shares of Exxon Mobil were up 0.8 percent at $90.20 while shares of Chevron were up 0.7 percent at $114.75.


S&P 500 earnings are expected to have risen 2.3 percent in the fourth quarter, Thomson Reuters data showed. Expectations for the quarter have fallen considerably since October when a 9.9 percent gain was estimated.


Volume was roughly 6.5 billion shares traded on the New York Stock Exchange, the Nasdaq and the NYSE MKT, compared with the 2012 average daily closing volume of about 6.45 billion.


Advancers outpaced decliners on the NYSE by about 22 to 7 and on the Nasdaq by about 2 to 1.


(Additional reporting by Chuck Mikolajczak; Editing by Kenneth Barry and Nick Zieminski)



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The Lede Blog: Live Updates on Armstrong's Oprah Interview

The Lede is rounding up online reaction to Lance Armstrong’s interview with Oprah Winfrey on Thursday night in real-time, with additional fact-checking and context provided by Juliet Macur and Sarah Lyall. The broadcast begins at 9 p.m. Eastern Time and will be streamed live on the Oprah Winfrey Network’s Web site.
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BlackBerry maker plans local skate, publicity in Waterloo to celebrate new phone






WATERLOO, Ont. – Call it BlackBerry Town, even if the name isn’t official.


In the lead up to the BlackBerry smartphone unveiling later this month, creator Research In Motion is turning its Waterloo, Ont., home base into a celebration of the device.






The company plans to decorate light poles in areas of Waterloo and neighbouring Kitchener with banners that promote its latest smartphone and thank the community for its support.


City councillors in Kitchener voted earlier this week to make an exception to rules that prevent corporations from using public property to advertise.


RIM says it is making plans for other events as well.


The company will hold skating rink parties at Kitchener City Hall and in Waterloo Town Square on Jan. 30 to coincide with the unveiling of its new BlackBerry devices.


Gadgets News Headlines – Yahoo! News




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Baby Boy on the Way for Kara DioGuardi




Celebrity Baby Blog





01/16/2013 at 08:15 PM ET



Baby Boy on the Way for Kara DioGuardi
Cindy Ord/Getty


Kara DioGuardi is going to be a mom!


The Grammy-nominated songwriter, who also served as a judge on American Idol‘s eighth and ninth seasons, confirms to PEOPLE exclusively that she and husband Mike McCuddy will welcome their first child via gestational surrogate in the coming weeks.


“We are eagerly awaiting the healthy and happy birth of our son Greyson James Carroll McCuddy,” DioGuardi, 42, tells PEOPLE.


After years of struggling with fertility issues and multiple failed IVF attempts, the couple, who wed in 2009, decided to explore other paths to parenthood — including adoption and surrogacy.


In the end, says DioGuardi, “We made a personal decision to try with a surrogate. I asked someone we knew, a friend. And on the first try, it worked.”


“We’re praying for our surrogate, that she gets through this and that it’s as easy on her as it can possibly be, because she’s been a gem throughout the whole process,” says the songwriter and music publisher.


“I’ve got two people on my mind: her and the baby. She’s given us this incredible gift.”


– Marisa Laudadio


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